17 Sep 2022

Medication Without Harm September 17, 2022

Introduction

Welcome to the quarterly Transfusion Evidence Round-Up

This is a collaboration between the International Society of Blood Transfusion (ISBT) and the Transfusion Evidence Library (TEL).  We aim to highlight high quality evidence randomised controlled trials and systematic reviews about an internationally relevant subject in the field of Transfusion Medicine.  All references are drawn from the Transfusion Evidence Library and, where relevant, Stem Cell Evidence.

This Transfusion Evidence Round-Up is sent to ISBT members and TEL subscribers, so if you are a subscriber to both mailing lists and receive it twice please bear with us until we can resolve this.
The Transfusion Evidence Library is produced by the Systematic Review Initiative (SRI) and funded by the four UK blood services. It is available free at the point of access providing a comprehensive and up-to-date database of high quality evidence in Transfusion Medicine.

The International Society of Blood Transfusion (ISBT) is a scientific society creating a community of transfusion medicine professionals from around the globe. ISBT works towards its vision of "a world of safe and sufficient blood" by undertaking advocacy for patient and donor safety, sharing knowledge to enhance transfusion practice and providing opportunities for education.

Top 10 articles

Ten articles are highlighted to bring attention to this year’s World Patient Safety Day - Medication Without Harm. 
These articles have been identified from the Transfusion Evidence Library and selected by ISBT members: Dr Danielle Valérie Domersant, Dr Gopal Kumar Patidar, and Professor Tadashi Matsushita

Top article

The efficacy of Roxadustat for the treatment of anemia in dialysis dependent chronic kidney disease patients: an updated systematic review and meta-analysis of randomized clinical trials.
Abdelazeem, B., et al. (2021). Annals of Translational Medicine.

Top article

The efficacy of Roxadustat for the treatment of anemia in dialysis dependent chronic kidney disease patients: an updated systematic review and meta-analysis of randomized clinical trials. Abdelazeem, B., et al. (2021). Annals of Translational Medicine. ​

PICO Summary

Selected articles

The efficacy and safety of roxadustat for the treatment of anemia in non-dialysis dependent chronic kidney disease patients: An updated systematic review and meta-analysis of randomized clinical trials.
Abdelazeem, B., et al. (2022). PloS One.

Thrombopoietin receptor agonists and rituximab for treatment of pediatric immune thrombocytopenia: A systematic review and meta-analysis of prospective clinical trials.
Ayad, N., Grace, R.F., and Al-Samkari, H., (2021). Pediatric Blood & Cancer.

Intravenous Iron Supplementation for the Treatment of Chemotherapy-Induced Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Buchrits, S., et al. (2022). Journal of Clinical Medicine.

Comparative Efficacy and Safety of Thrombopoietin Receptor Agonists in Adults With Thrombocytopenia: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.
Deng, J., et al. (2021). Frontiers in Pharmacology.

Promoting awareness of donation-related iron depletion among high risk blood donors.

France, J.L., et al. (2021). Transfusion.

Efficacy and Safety of Daprodustat Vs rhEPO for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis and Trial Sequential Analysis.
Fu, Z., et al. (2022). Frontiers in Pharmacology.

Serum or plasma ferritin concentration as an index of iron deficiency and overload.
Garcia-Casal, M.N., et al. (2021). The Cochrane Database of Systematic Reviews.

Sustained low-dose prophylactic early erythropoietin for improvement of neurological outcomes in preterm infants: A systematic review and meta-analysis.
Liang, L., et al. (2021). Journal of Affective Disorders.

Comparative efficacy of 19 drug therapies for patients with idiopathic thrombocytopenic purpura: a multiple-treatments network meta-analysis.
Zhou, H., et al. (2022). Annals of Hematology

Live Journal Club

On September 26, 2022, the TER coordinators Allison Mo, Susan Brunskill and Catherin Kimber organised a Live Journal Club where they invited the reviewers to discuss selected papers from the Round-Up.

Watch the Live Journal Club Recording:

 

Editorial Board

Tadashi Matsushita

Tadashi Matsushita

Professor, Nagoya University Hospital Department of Blood Transfusion Service, Japan

Dr Danielle Valérie Domersant
Gopal Patidar

Gopal Patidar

Haemovigilance Working Party Secretary, Associate Professor, Department of Transfusion Medicine, AIIMS, New Delhi, India